Veterinary Pharmacology and Therapeutics

Veterinary Pharmacology and Therapeutics, Ninth Edition is the long awaited update of the gold-standard reference on veterinary pharmacology and therapeutics. The field of veterinary pharmacology continues to evolve and expand and this new edition has been revised to reflect changes in the field. Veterinary Pharmacology and Therapeutics, Ninth Edition is thoroughly revised, updated, and expanded to meet the needs of today’s veterinarians, veterinary students, and animal health researchers.

Preface xv

Section 1. Principles of Pharmacology 3

1. Veterinary Pharmacology: An Introduction to the Discipline 5 
Jim E. Riviere and Mark G. Papich

2. Absorption, Distribution, Metabolism, and Elimination 11 
Jim E. Riviere

3. Pharmacokinetics 47
Jim E. Riviere 

4. Mechanisms of Drug Action and Pharmacokinetics/Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine 75
Pierre-Louis Toutain 

Section 2. Drugs Acting on the Autonomic Nervous System 99

5. Introduction to Neurohumoral Transmission and the Autonomic Nervous System 101
H. Richard Adams.

6. Adrenergic Agonists and Antagonists 125
H. Richard Adams.

7. Cholinergic Pharmacology: Autonomic Drugs 157
H. Richard Adams

Section 3. Anesthetics and Analgesics 181

8. Introduction to Drugs Acting on the Central Nervous System and Principles of Anesthesiology 183 
Peter J. Pascoe and Eugene P. Steffey

9. Neuromuscular Blocking Agents 211
H. Richard Adams

10. Inhalation Anesthetics 229 
Eugene P. Steffey

11. Injectable Anesthetic Agents 265 
Lysa P. Posner and Patrick Burns

12. Opioid Analgesic Drugs 301 
Butch KuKanich and Mark G. Papich

13. Sedative Agents: Tranquilizers, Alpha-2 Agonists, and Related Agents 337 
Lysa P. Posner and Patrick Burns

14. Local Anesthetics 381 
Alistair I. Webb and Luisito S. Pablo

15. Euthanizing Agents 401 
Alistair I. Webb

Section 4. Autacoids and Anti-inflammatory Drugs 409

16. Histamine, Serotonin, and Their Antagonists 411 
H. Richard Adams

17. Peptides: Angiotensin and Kinins 429
H. Richard Adams

18. Prostaglandins, Related Factors, and Cytokines 439
H. Richard Adams

19. Analgesic, Anti-inflammatory, Antipyretic Drugs 457 
Peter Lees

20. Anticonvulsant Drugs 493
Mark G. Papich

21. Drugs Affecting Animal Behavior 509
Barbara L. Sherman and Mark G. Papich

Section 5. Drugs Acting on the Cardiovascular System 539

22. Digitalis, Positive Inotropes, and Vasodilators 541
Matthew W. Miller and H. Richard Adams

23. Antiarrhythmic Agents 575 
Matthew W. Miller and H. Richard Adams 

Section 6. Drugs Affecting Renal Function and Fluid-Electrolyte Balance 603

24. Principles of Acid-Base Balance: Fluid and Electrolyte Therapy 605
Deborah T. Kochevar and Maya M. Scott

25. Diuretics 647 
Deborah T. Kochevar

Section 7. Drugs Acting on Blood and Blood Elements 671

26. Hemostatic and Anticoagulant Drugs 673
H. Richard Adams

Section 8. Endocrine Pharmacology 691

27. Hypothalamic and Pituitary Hormones 693
Srujana Rayalam, Margarethe Hoenig, and Duncan Ferguson

28. Hormones Affecting Reproduction 717
Doodipla S. Reddy and John E. Gadsby

29. Thyroid Hormones and Antithyroid Drugs 735 
Duncan C. Ferguson

30. Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs 771 
Duncan C. Ferguson, Levent Dirikolu, and Margarethe Hoenig

31. Drugs Influencing Glucose Metabolism 803
Margarethe Hoenig

Section 9. Chemotherapy of Microbial Diseases 817

32. Antiseptics and Disinfectants 819 
Mark C. Heit and Jim E. Riviere

33. Sulfonamides and Potentiated Sulfonamides 835 
Mark G. Papich and Jim E. Riviere

34. β-Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs 865
Mark G. Papich and Jim E. Riviere

35. Tetracycline Antibiotics 895 
Mark G. Papich and Jim E. Riviere

36. Aminoglycoside Antibiotics 915 
Mark G. Papich and Jim E. Riviere

37. Chloramphenicol and Derivatives, Macrolides, Lincosamides, and Miscellaneous Antimicrobials 945 
Mark G. Papich and Jim E. Riviere

38. Fluoroquinolone Antimicrobial Drugs 983
Mark G. Papich and Jim E. Riviere

39. Antifungal and Antiviral Drugs 1013
Jennifer L. Davis, Mark G. Papich, and Mark C. Heit

Section 10. Chemotherapy of Parasitic Diseases 1051

40. Antinematodal Drugs 1053 
Carlos E. Lanusse, Luis I. Alvarez, Juan M. Sallovitz, María L. Mottier, and Sergio F. Sanchez Bruni 

41. Anticestodal and Antitrematodal Drugs 1095
Carlos E. Lanusse, Guillermo L. Virkel, and Luis I. Alvarez

42. Macrocyclic Lactones: Endectocide Compounds 1119
Carlos E. Lanusse, Adrian L. Lifschitz, and Fernanda A. Imperiale

43. Antiprotozoan Drugs 1145 
Jennifer L. Davis and Jody L. Gookin

44. Ectoparasiticides 1181 
Ronald E. Baynes

Section 11. Specialty Areas of Pharmacology 1203

45. Chemotherapy of Neoplastic Diseases 1205
Gordon L. Coppoc

46. Immunosuppressive Drugs and Cyclosporine 1233 
Mark G. Papich

47. Drugs Affecting Gastrointestinal Function 1247
Mark G. Papich

48. Dermatopharmacology: Drugs Acting Locally on the Skin 1273 
Jim E. Riviere

49. Drugs that Affect the Respiratory System 1295
Mark G. Papich

50. Pharmacogenomics 1313 
Katrina L. Mealey

51. Therapeutic Drug Monitoring 1323
Mark G. Papich

52. Considerations for Treating Minor Food-Producing Animals with Veterinary Pharmaceuticals 1331 
Lisa A. Tell, Margaret Oeller, and Arthur L. Craigmill

53. Zoological Pharmacology 1343
Robert P. Hunter

Section 12. Regulatory Considerations. 1353

54. Legal Control of Veterinary Drugs 1355
Stephen F. Sundlof

55. Drug Approval Process 1365 
Marilyn Martinez, Melanie Berson, Bernadette Dunham, Joan Gotthardt, and Laura Hungerford

56. Veterinary Pharmacy 1407 
Gigi Davidson

57. Regulation of Drug and Medication Use in Performance Animals 1419 
Cynthia A. Cole and Keith Zientek

58. Adverse Drug Reactions 1431 
Victoria Hampshire and Margarita A. Brown

59. Dosage Forms and Veterinary Feed Directives 1439 
Jim E. Riviere and Geof W. Smith

60. USP’s Role in Veterinary Pharmacology and Evidence-Based Information 1445
Cory Langston, Stefan Schuber, and Ian R. DeVeau

61. Chemical Residues in Tissues of Food Animals 1453
Jim E. Riviere and Stephen F. Sundlof

Index 1463