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Protein Interaction Networks: Computational Analysis

441,60 lei

LibrariaDelfin.ro

Authors Aidong Zhang
Publisher Cambridge University Press
Year 2009
Pages 292
SKU: I26xDfyk6OExaZ1dVnsA Category:
Additional information
General
Authors Aidong Zhang
Publisher Cambridge University Press
Year 2009
Others
Identification
ISBN-13 9780521888950
Format
Pages 292
Description

The analysis of protein-protein interactions is fundamental to the understanding of cellular organization, processes, and functions. Recent large-scale investigations of protein-protein interactions using such techniques as two-hybrid systems, mass spectrometry, and protein microarrays have enriched the available protein interaction data and facilitated the construction of integrated protein-protein interaction networks. The resulting large volume of protein-protein interaction data has posed a challenge to experimental investigation. This book provides a comprehensive understanding of the computational methods available for the analysis of protein-protein interaction networks. It offers an in-depth survey of a range of approaches, including statistical, topological, data-mining, and ontology-based methods. The author discusses the fundamental principles underlying each of these approaches and their respective benefits and drawbacks, and she offers suggestions for future research.