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Protein Interaction Networks: Computational Analysis
441,60 lei
Authors | Aidong Zhang |
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Publisher | Cambridge University Press |
Year | 2009 |
Pages | 292 |
Additional information
General | |
---|---|
Authors | Aidong Zhang |
Publisher | Cambridge University Press |
Year | 2009 |
Others | |
Identification | |
ISBN-13 | 9780521888950 |
Format | |
Pages | 292 |
Description
The analysis of protein-protein interactions is fundamental to the understanding of cellular organization, processes, and functions. Recent large-scale investigations of protein-protein interactions using such techniques as two-hybrid systems, mass spectrometry, and protein microarrays have enriched the available protein interaction data and facilitated the construction of integrated protein-protein interaction networks. The resulting large volume of protein-protein interaction data has posed a challenge to experimental investigation. This book provides a comprehensive understanding of the computational methods available for the analysis of protein-protein interaction networks. It offers an in-depth survey of a range of approaches, including statistical, topological, data-mining, and ontology-based methods. The author discusses the fundamental principles underlying each of these approaches and their respective benefits and drawbacks, and she offers suggestions for future research.